Kinetic Parameter

Description

Reference

KAICAR

Michaelis Menten constant of AICAR transformylase converting AICAR to FAICAR

[S1]

kDHFR

Rate constant of dihydrofolate reductase converting DHF to THF

[S2]

KDHFR

Michaelis Menten constant for dihydrofolate reductase converting DHF to THF

[S2]

KFTCD

Michaelis Menten constant for 5-formimino-THF cyclodeaminase converting 5-formimino-THF to 5,10-methenyl-THF

[S3]

kFTCL

Rate constant of 5-formyl THF cycloligase converting 5-formyl THF to 5,10-methenyl THF

[S4]

KFTS

Michaelis Menten constant for formyl-THF synthetase converting formate to 10-formyl-THF

[S5]

KGDC

Michaelis Menten constant for glycine decarboxylase converting THF to 5,10-methylene THF

[S6]

kGF

Second order conversion rate of glyoxylate to formate

[S7]

KGFT

Michaelis Menten constant for glutamate formiminotransferase converting formiminoglutamate to 5-formimino-THF

[S8]

KGSYN

Michaelis Menten constant for glyoxylate synthetase converting formate to glyoxylate

[S9]

KGTF

Michaelis Menten constant for GAR transformylase converting GAR to FGAR

[S10]

KKHMT

Michaelis Menten constant for ketopantoate hydroxymethyltransferase converting a-KIVA to THF and ketopantoate

[S11]

kMHF_GAR

Rate constant for GAR transformylase converting 10-formyl-THF to THF

[S10]

KMTC

Michaelis Menten constant for 5,10-methylene THF cyclohydrolase converting 5,10-methenyl-THF to 10-formyl-THF

[S12]

KMTD

Michaelis Menten constant for 5,10-methylene THF dehydrogenase converting 5,10-methylene-THF to 5,10-methenyl-THF

[S12]

kMTR

Rate constant for methylene THF reductase converting 5,10-methylene-THF to 5-methyl-THF

[S13]

KMTR

Michaelis Menten constant for methylene THF reductase converting 5,10-methylene-THF to 5-methyl-THF

[S13]

KMTS

Michaelis Menten constant for methionine synthase converting homocysteine to methionine

[S14]

kSHM

Rate constant for serine hydroxymethyltransferase converting 5,10-methenyl-THF to 5-formyl-THF

[S15]

KSHM

Michaelis Menten constant for serine hydroxymethyl transferase converting 5,10-methenyl-THF to 5-formyl-THF

[S15]

kSHMT

Rate constant for serine hydroxymethyltransferase converting serine to glycine

[S16]

KSHMT

Michaelis Menten constant for serine hydroxymethyltransferase converting serine to glycine

[S16]

kTFA

Rate constant for the association of THF and Formaldehyde to 5,10-methylene-THF

[S17]

kTFD

Rate constant for the dissociation of 5,10-methylene-THF to THF and Formaldehyde

[S17]

KTS

Michaelis Menten for thymidylate synthase induced synthesis of thymidylate from 5,10-methenyl-THF

[S18]

VAICAR

Vmax of AICAR transformylase converting AICAR to FAICAR

[S1]

VFTCD

Vmax for 5-formimino-THF cyclodeaminase converting 5-formimino-THF to 5,10-methenyl-THF

[S3]

VFTS

Vmax for formyl-THF synthetase converting formate to 10-formyl-THF

[S5]

VGDC

Vmax for glycine decarboxylase converting THF to 5,10-methylene THF

[S6]

VGFT

Vmax for glutamate formiminotransferase converting formiminoglutamate to 5-formimino-THF

[S8]

VGSYN

Vmax for glyoxylate synthetase converting formate to glyoxylate

[S9]

VGTF

Vmax for GAR transformylase converting GAR to FGAR

[S10]

VKHMT

Vmax for ketopantoate hydroxymethyltransferase converting a-KIVA to THF and ketopantoate

[S34]