1

Alvarez Uria G. et al. (2013) [25]

Andhra Pradesh

(Rural)

247

The cumulative incidence of attrition was 12.6% (95% confidence interval, 8.7 - 17.3) after five years of follow-up. Children who belong to scheduled tribes had a higher risk of delayed ART initiation and LTFU. Orphan children had a higher risk of delayed ART initiation and mortality.

2

Alvarez Uria G. et al. (2014) [26]

Andhra Pradesh

(Rural)

282

The cumulative incidence of attrition (mortality and LTFU) was 15.6% at five years, and the attrition rate was higher during the first year after enrolment in care.

3

Banerjee et al. (2010) [27]

West Bengal

(NM)

180

Median duration of survival from date of diagnosis was 15.1 years. Those who received HAART survived significantly longer.

4

Bhattacharya et al. (2011) [28]

Delhi

(Urban)

90

Mean adherence was 91.4%. Adherence was low (<95%) in 31 (34.4%) patients. On multivariate logistic regression analysis, increasing time since ART initiation, low caregiver educational status, orphan hood, efavirenz-based ART regimens and female gender were associated with lower adherence.

5

Bhattacharya et al. (2012) [29]

NA

87

The outcome of ART in terms of survival was not affected by the orphan status. Improvement in nutritional parameters and CD4 count was comparable in both the groups.

6

Chaudhary et al. (2012) [30]

Delhi

(Urban)

130

Following ART, a reduction in wasting was noted in 75.0% of children ≤5 years of age, whereas only 44.4 % of underweight children >5 years of age showed an improvement after therapy.

8

Seth A. et al. (2014) [31]

Kolkata

(Urban)

106

Median duration of ART was 25 (IQR 16 - 35) months. The desired adherence level of >95% during six months of review assessed by pill count was achieved in 95.3% children. The 3-day recall method yielded >95% adherence in 99% children (p ≤ 0.001).

9

Violari et al. (2012) [32]

Tamil Nadu

(NM)

288

The median percentage of CD4+ T cells was 15%. The percentage of children who reached the primary end point was significantly higher in the nevirapine group than in the ritonavir-boosted lopinavir group (40.8% vs. 19.3%; p < 0.001). The time to a protocol-defined toxicity end point was shorter in the nevirapine group (p = 0.04), as was the time to death (p = 0.06).

10

De et al. (2012) [33]

West Bengal

(Urban)

94

Fifty-six percent of respondent parents and 65.8% of respondent children showed good adherence to ART.

11

Rajashekharan et al. (2009) [34]

Tamil Nadu

(Urban)

NA

The cumulative survival probability at 6, 12, 18, 24 and 30 months was 93%, 90%, 89.7%, 89.7% and 89.7%, respectively. Of the children who died, about 50% died within the first month. Nearly 6% of the children had adherence less than 95%. The children who had a baseline CD4 % less than or equal to 14% had significantly (p < 0.05) higher mortality as compared to children who had 20% or more.

Survival of children living with HIV

1

Alvarez Uria G. et al. (2013) [36]

Andhra Pradesh

(Rural)

523

Predictors for delayed entry into care and survival were; diagnosed after knowing that parent is HIV positive, age less than 18 month, alive parent, female sex, diagnosed at earlier calendar years, distance at ART center >90 minutes .

2

Gupta et al. (2013) [37]

Pune

(Urban)

32

The delayed entry into care i.e. delay in diagnosis was associated with incidence of opportunistic infection and survival

3

Radhakrishnan et al. (2013) [38]

Tamil Nadu

(NM)

26

All 26 (13 female and 13 male) perinatally HIV infected children, born during 1991-1996 were healthy until 2006. But by 2011, 18 were placed in progressors group with antiretroviral therapy (ART), while six remained in non progressors group and two died. AIDS free median survival period (years) in long term progressors group (CD4 count) of the cohort was 10 ± 0.66 (<200; p ≤ 0.05); 11 ± 0.61 (200 - 350, p ≤ 0.05), 12 ± 0.18 (>350, p ≤ 0.05). Intercurrent and opportunistic infections (OIs) were observed in long term progressors only. The incidence of opportunistic infections in long term progressors was higher when compared to general pediatric population.