Authors

Antifungal profile

Gene mutations

ERG11

ERG9

ERG3

ERG2

FKS1HP1

TAC1b

MRR1

References

VF125AL

Y132F

Y132F/L125F

E343D/N335S/K177A

M351V/A27T

S58T

E39D

S639P

D642Y

T125I/C1253fs/G1250S

L148I/R937S/I701V/I694V

S195G

A651P

A657V

N647T

Multiple

Number of isolates with a mutation in clade I

Maphanga and Naicker

Fluconazole

S

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

[32] [34]

R

-

14

-

-

-

-

-

-

-

1

-

1

8

-

-

Echinocandin

S

-

-

-

-

-

-

-

-

3

-

-

-

-

-

-

-

R

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

Oladele

Fluconazole

S

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

[44]

R

-

-

2

-

-

-

1

-

-

-

-

-

-

-

-

-

Number of isolates with a mutation in clade III

Maphanga and Naicker

Fluconazole

S

8

-

-

-

-

-

-

-

-

-

-

-

1

-

8

-

[32] [34]

R

68

-

-

-

-

-

-

-

-

-

-

1

15

-

68

-

Echinocandin

S

-

-

-

-

-

-

-

1

-

1

-

-

-

-

-

-

R

-

-

-

-

-

-

-

2

-

-

-

-

-

-

-

-

Number of isolates with a mutation in clade IV

Maphanga and Naicker

Fluconazole

S

-

-

-

1

-

-

-

-

-

-

-

-

-

-

-

-

[32] [34]

R

-

-

-

2

-

-

-

-

-

-

-

-

-

-

-

-

Amphotericin B

S

-

-

-

-

1

2

-

-

-

-

-

-

-

-

-

1

R

-

-

-

-

1

-

-

-

-

-

-

-

-

-

-

-

Oladele

Fluconazole

S

-

-

-

2*

-

-

-

-

-

-

-

-

-

-

-

-

[44]

R

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-