Compound

R'

Cell lines

HT-29

HELA

A-549

FE1

Methyl

126 ± 1

92 ± 2

101 ± 2

FE2

Ethyl

94 ± 2

70 ± 2

92 ± 1

FE3

n-propyl

75 ± 2

64 ± 2

60 ± 1

FE4

Isopropyl

92 ± 2

138 ± 2

NA

FE5

n-butyl

74 ± 1

61 ± 2

83 ± 2

FE6

Isobutyl

96 ± 1

105 ± 2

NA

FE7

t-butyl

NA

127 ± 2

108 ± 1

FE8

n-pentyl

77 ± 1

69 ± 1

95 ± 1

FE9

2-pentyl

92 ± 2

89 ± 2

98 ± 2

FE10

Chloro ethyl

19 ± 2

32 ± 1

43 ± 2

FE11

Bromo ethyl

50 ± 2

55 ± 2

20 ± 1

Methotrexate

12 ± 1

9 ± 1

5 ± 1