Compound | R' | Cell lines | ||
HT-29 | HELA | A-549 | ||
FE1 | Methyl | 126 ± 1 | 92 ± 2 | 101 ± 2 |
FE2 | Ethyl | 94 ± 2 | 70 ± 2 | 92 ± 1 |
FE3 | n-propyl | 75 ± 2 | 64 ± 2 | 60 ± 1 |
FE4 | Isopropyl | 92 ± 2 | 138 ± 2 | NA |
FE5 | n-butyl | 74 ± 1 | 61 ± 2 | 83 ± 2 |
FE6 | Isobutyl | 96 ± 1 | 105 ± 2 | NA |
FE7 | t-butyl | NA | 127 ± 2 | 108 ± 1 |
FE8 | n-pentyl | 77 ± 1 | 69 ± 1 | 95 ± 1 |
FE9 | 2-pentyl | 92 ± 2 | 89 ± 2 | 98 ± 2 |
FE10 | Chloro ethyl | 19 ± 2 | 32 ± 1 | 43 ± 2 |
FE11 | Bromo ethyl | 50 ± 2 | 55 ± 2 | 20 ± 1 |
Methotrexate |
| 12 ± 1 | 9 ± 1 | 5 ± 1 |