FOLFIRI with BVZ November 2008 to March 2009

Regional radiology CT October 2009

Recurrence

Phase II study with panitumumab February 2010

Single agent trial-placebo February 2010 to August 2010

Regional radiology CT August 2010

Recurrence

Panitumumab August 2010 to February 2011

Regional radiology CT February 2011

Recurrence

Irinotecan and panitumumab February 2011 to May 18, 2011

Cancer institute CT August 19, 2011

Recurrence

BC. September 22, 2011 PB, erlotinib, capecitabine, oxaliplatin, BVZ, pazopanib

Regional radiology CT December 16, 2011

PR

VEGF, EGFR, HER-2-elevated (blood), BRAF and KRAS-wild-type, PTEN and TS-reduced, MGMT-negative (Caris-tissue analysis)

15

Regional hospital April 2006

Adenocarcinoma of the colon, moderately differentiated

Regional hospital CT January 12, 2009

Nodules in the lungs

Colectomy April 2006

January 13, 2009 (lung nodule biopsy)

Adenocarcinoma, moderately differentiated of colonic origin

Capecitabine June 2006 to November 2006

Regional radiology CT January 12, 2009

Recurrence (lungs)

Capecitabine, oxaliplatin, BVZ February 17, 2009 to August 2009

Capecitabine, irinotecan, BVZ. February 2010 to August 2010

Regional radiology CT January 18, 2011

Recurrence (lungs)

Regional radiology CT September 14, 2011

Recurrence (lungs)

BC. December 13, 2011 PB, pazopanib, everolimus, dasatinib

Regional radiology March 13, 2012

SD

VEGF-elevated (blood), ERCC1, TS, and PTEN-negative, SRC, PDGFRB, and HIF1A-overexpressed, VHL-reduced, BRAF-wild-type, (Caris-tissue analysis)