BC. July 8, 2008 PB, sorafenib, vorinostat, BVZ

Regional radiology PET/CT November 24, 2008

SD

Molecular profiling-negative (blood)

9

University hospital February 2007

Adenocarcinoma of the rectum

University hospital CT March 9, 2007

Rectal tumor with regional lymph node metastases

Capecitabine and RT, 50 Gy to March 29, 2007

University hospital March 7, 2008

Liver metastases from adenocarcinoma of the rectum

Tumor resection colostomy July 25, 2007

FOLFOX August 8, 2007 ×4

University hospital CT September 25, 2007

Recurrence (liver metastases)

FOLFIRI with BVZ November 11, 2007 to January 23, 2008

Hemi-hepatectomy March 3, 2008

Laparotomy for fistula repair 2× to June 17, 2008

University hospital CT September 23, 2008

Recurrence (multiple live metastases)

University hospital PET November 26, 2008

Recurrence (lung, liver, and pelvic metastases)

BC. January 13, 2009 PB, capecitabine, erlotinib, BVZ, sirolimus, vorinostat (discontinued) May 4, 2009

Regional radiology PET/CT September 8, 2009

SD (resolution of hypermetabolic nodules in the lungs and liver)

EGFR and VEGF-(blood) KRAS-wild-type

10

Regional hospital February 14, 2007

Metastatic adenocarcinoma to the liver consistent with colorectal primary

Regional radiology January 31, 2007

Multiple liver metastases, thickening in rectal area and enlarged perirectal lymph nodes.

Xelox, BVZ and cisplatin (clinical trial) March 2007 ×4

Capecitabine and BVZ to November 2008

Regional radiology PET/CT November 13, 2008

Recurrence (liver metastases)

FOLFIRI November 29, 2008 to January 7, 2009

Regional radiology PET/CT January 22, 2009

Persistent disease

BC. January 23, 2009 PB, FOLFIRI, BVZ

Regional radiology CT/PET April 23, 2009

SD

Molecular profiling-negative (blood)

11

Regional hospital June 25, 2007

Adenocarcinoma of the sigmoid colon

Regional radiology PET/CT November 25, 2008

Bilateral pulmonary nodules

Hemicolectomy June 21, 2007

FOLFOX August 15, 2007 to February 5, 2008

Regional radiology PET/CT November 25, 2008

Recurrence

Irinotecan and BVZ

Regional radiology PET/CT September 30, 2009

Recurrence (pulmonary nodules)