Symbol | Gene Name | Gene Function | Microarray Fold Change | p-Value |
PHK | Phosphorylasekinase, delta | Catalyzes phosphorylation of serine in substrates. Increases glycogenolysis. | −1.743 | 6.50E−06 |
PRKCD | Protein kinase C delta | Functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, may impair insulin secretion due to apoptosis. | −1.63 | 6.28E−05 |
PYGL | Phosphorylase, glycogen, liver | Rate-determining enzyme catalyzing glycogen degradation. | −1.50 | 1.66E−03 |
PPP1R3C | Protein phosphatase 1, regulatory (inhibitor) subunit 3C | Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. Dramatically increases basal and insulin-stimulated glycogen synthesis. | +1.69 | 1.37E−03 |
PFKM | Phosphofructokinase, muscle | Catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-bisphosphate, prior to its cleavage into glyceraldehyde-3-phosphate which enters the energy generation phase of glycolysis. | +2.27 | 1.47E−07 |