Symbol

Gene Name

Gene Function

Microarray Fold Change

p-Value

PHK

Phosphorylasekinase, delta

Catalyzes phosphorylation of serine in substrates. Increases glycogenolysis.

−1.743

6.50E−06

PRKCD

Protein kinase C delta

Functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, may impair insulin secretion due to apoptosis.

−1.63

6.28E−05

PYGL

Phosphorylase, glycogen, liver

Rate-determining enzyme catalyzing glycogen degradation.

−1.50

1.66E−03

PPP1R3C

Protein phosphatase 1, regulatory (inhibitor) subunit 3C

Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. Dramatically increases basal and insulin-stimulated glycogen synthesis.

+1.69

1.37E−03

PFKM

Phosphofructokinase, muscle

Catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-bisphosphate, prior to its cleavage into glyceraldehyde-3-phosphate which enters the energy generation phase of glycolysis.

+2.27

1.47E−07