Mean ± SD

n

BL

3M

6M

9M

12M

p value

[eGFR ≥ 60] SCr (mg/dl)

25

0.78 ± 0.13

0.80 ± 0.14

0.78 ± 0.11

0.78 ± 0.14

0.80 ± 0.14

0.263^a

[eGFR < 60] SCr (mg/dl)

23

1.45 ± 0.60

1.44 ± 0.64

1.55 ± 0.88

1.35 ± 0.54

1.44 ± 0.71

0.596^a

eGFR ≥ 60 (ml/min/1.73 m²)

25

74.0 ± 11.6

72.0 ± 10.0

73.6 ± 8.2

75.0 ± 12.9

72.4 ± 14.1

0.219^a

eGFR < 60 (ml/min/1.73 m²)

22

39.8 ± 12.2

42.8 ± 15.1

41.7 ± 17.1

45.0 ± 16.8

44.0 ± 17.2

0.387^a

[eGFR ≥ 60] BUN (mg/dl)

17

16.2 ± 3.3

16.3 ± 2.6

17.2 ± 3.4

17.1 ± 3.1

18.0 ± 4.2

0.199^a

[eGFR < 60] BUN (mg/dl)

19

26.6 ± 8.7

27.3 ± 9.3

29.3 ± 13.9

25.3 ± 9.9

26.4 ± 11.5

0.564^a

UA (mg/dl)

19

6.3 ± 1.4

6.4 ± 1.2

6.4 ± 1.3

6.4 ± 1.2

6.3 ± 1.2

0.828^b

Alb (g/dl)

10

4.2 ± 0.2

4.2 ± 0.2

4.2 ± 0.2

4.2 ± 0.0

4.2 ± 0.2

0.992^b

Hb (g/dl)

19

13.6 ± 1.4

13.6 ± 1.6

13.4 ± 1.7

13.3 ± 1.9

13.4 ± 2.0

0.239^b

K (mEq/l)

20

4.5 ± 0.4

4.6 ± 0.5

4.5 ± 0.5

4.5 ± 0.2

4.8 ± 0.5

0.135^a

UP

31

0.3 ± 0.8

0.2 ± 0.5

0.3 ± 0.7

0.2 ± 0.5

0.2 ± 0.5

0.251^a

HbA1c (%)

164

7.4 ± 0.9

7.3 ± 0.9

7.2 ± 1.0

7.1 ± 0.9

7.1 ± 1.0

<0.001^***a

FBG (mg/dl)

23

140.0 ± 30.0

134.0 ± 26.0

135.7 ± 29.1

136.0 ± 32.3

142.2 ± 30.5

0.220^a

non HDL-c (mg/dl)

8

134.9 ± 24.2

147.8 ± 32.4

130.0 ± 23.0

130.0 ± 21.0

134.1 ± 20.4

0.261^b

TG (mg/dl)

14

144.5 ± 116.8

142.3 ± 114.4

123.6 ± 55.3

125.6 ± 53.7

104.1 ± 40.2

0.736^a

Systolic blood pressure (mmHg)

220

135.7 ± 17.6

128.7 ± 14.6

127.7 ± 13.7

128.0 ± 15.3

129.9 ± 14.0

<0.001^***a

Diastolic blood pressure (mmHg)

220

75.4 ± 10.7

72.8 ± 9.0

72.3 ± 9.3

72.8 ± 8.9

73.1 ± 8.2

<0.001^***a

BMI

216

24.8 ± 4.2

24.6 ± 4.2

24.5 ± 4.2

24.4 ± 4.2

24.3 ± 4.2

<0.001^***a