Productivity loss based on data from SD	Lost productivity attributable to diabetes were accounted for through an estimation of 1) Annual mean gross income difference from expected income given educational level, gender and age; 2) Premature mortality; 3) Abseentism. 1) Sum of absolute difference in annual gross income between PwD and controls aggregated for patients older than 14 years and younger than 69 in strata by gender, age in 5 year intervals and four educational levels (1: < 11 years of education; 2: < 16years; 3: < 18 years and 4: 18+ years) 2) Sum of annual foregone income due to lost years of productivity in cases of premature death for: 2a) 2011 and 2b) productivity loss in 2011 due to deaths attributable to diabetes occurred prior to 2011. Since data is not available on deaths attributable to diabetes for the past 45 years, we used attributable deaths in 2011 and the production loss that will incur in the future until the age of 69 to mirror the foregone production well knowing that this method builds on the simplified assumption that diabetes mortality and labour market patterns the past decades have not changed. For persons between the age of 15 and 69, number of relative deaths by gender and 10-year age group was compared between PwD and controls and the difference is assumed to represent deaths attributable to diabetes. Number of attributable deaths in each strata was multiplied with the average wage of a diabetes-free person in that strata. 2a) Strata were aggregated and the sum was divided by 2 assuming deaths are equally spread over the entire calendar year. 2b) Mid age in each age-interval was used as proxy and then number of years until the age of 69 was calculated and multiplied with number of attributable deaths in the given strata again multiplied with the average annual gross income among a diabetes-free person in that strata. 3) Number of days of absence due to diabetes is calculated based on literature estimates of 3 extra days a year. Daily wage is calculated as the mean annual income among PwD divided by 200 working days.
SMBG costs (meters and sticks) and insulin pumps	Cost of SMBG (for the 22% of PwD using insulin) was estimated on the basis of a study of SMBG costs in Canada to annually 860 US$ equivalent to 6175 DKK (2011 prices) [32] . According to the Danish Ministry of Health and the Danish Diabetes Association [33] pumps were used by approximately 2100 PwD and the annual cost ranged from 22,000 to 39,000 DKK in 2010. For 2011,we have applied a conservative cost estimate of 22000 DKK for80% of all T1 children (0-14 year) and for 5% of the rest of the T1 population in total amounting to 2450 PwD. Censors are not included in this cost and would approx. double the annual cost of pumps.
Appliances (blind assistance, protese crus, femur, wheel chairs, sticks)	Unit costs of blind assistance was calculated on the basis of the MTV report [34] and includesassistance outside home, sticks and guide dogs, IT solutions for blind parents, blind library appliances and amounted to 99,137 DKK per year (2011 prices). The cost cover needs for the 1.1% -1.6% (amounting to approx. 3372 persons) of the diabetes population that is considered socially blind [34] . The cost of a crus and femur prosthesis was estimated to be respectively 17,000 and 44,000 DKK per year. In 2011, 1348 (crus) and 768 (femur) persons with diabetes lived with an amputation and respectively 75% and 50% of those were assumed to have a prosthesis. The rest of the amputated persons are assumed to use wheel chairs. The cost of wheel chairs was calculated from an average of different chair types (ranging from a cost of 2,589 to 34,109 DKK) [35] to an annual average cost of 2,450 DKK. 25% of diabetes patients (above 45 years) with complications are assumed to need a wheel chair.
Prevention, education and psychological assistance	A total of 4 hours per diabetes patient under 29 years (3%) and all persons diagnosed during 2011 (10%) and 1 hour for 50% of the rest of the diabetic population was applied as an estimate of the received support in any of the following forms (prevention initiatives, educational training or psychological assistance, telemedicine etc.) An hourly cost of 588 DKK was applied.
Patients’ own time to monitor their disease and informal care takers support for relatives (0-15 years and above 75 years)	According to an evaluation [36] [37] by diabetes educators, experienced diabetes patients controlled by oral agents would use 2 hours a day when asked to follow the American Diabetes Association self-care recommendation and elderly and handicapped patients would use more. Exercise and diet, required for self-care of many chronic conditions, are the most time-consuming tasks. We included a conservative estimate of patients’ time (1 hour per week per patient) and informal caregivers’ time (8 hours per year per patient) at a cost of 25% of the productive value.
Depreciation	Data on costs of capital depreciation in secondary care and for nursing services were included with 20% of secondary care and nursing costs.