Baseline

Week 3

Week 6

Active

Placebo

Active

Placebo

Active

Placebo

GSRS total

7.7 ± 2.5

7.5 ± 2.0

4.6 ± 2.8*

5.8 ± 2.8*

4.9 ± 2.9*

6.2 ± 3.2*

IBSSS total

12.5 ± 5.1

11.8 ± 4.1

7.0 ± 4.2*

9.4 ± 5.5

7.9 ± 5.1*

10.7 ± 5.7

PAC-QOL total

32.8 ± 15.7

42.1 ± 7.8

25.5 ± 15.9

40.1 ± 19.7

29.2 ± 10.7^a

44.8 ± 17.2