Name of drug | Type of drug | Standard dose and dose range in mg | Indications |
Melphalan | Nitrogen mustard derivative alkylating agent | 5 (3 - 7.5) | As a single agent for (group B and C). |
Topotecan | Topoisomerase 1 inhibitor, semi-synthetic camptothecin derivative | 1 (1 - 2) | Group (D and C) advanced retinoblastoma with diffuse vitreous seeds. |
Carboplatin | Is a platinum-based derivative | 20 (15 - 30) | Bilateral IAC to avoid the cumulative toxicity of melphalan. Recurrence after IAC, Suboptimal response to combination of melphalan and topotecan. |