Name of drug

Type of drug

Standard dose and dose range in mg

Indications

Melphalan

Nitrogen mustard derivative alkylating agent

5 (3 - 7.5)

As a single agent for (group B and C).

Topotecan

Topoisomerase 1 inhibitor, semi-synthetic camptothecin derivative

1 (1 - 2)

Group (D and C) advanced retinoblastoma with diffuse vitreous seeds.

Carboplatin

Is a platinum-based derivative

20 (15 - 30)

Bilateral IAC to avoid the cumulative toxicity of melphalan.

Recurrence after IAC, Suboptimal response to combination of melphalan and topotecan.