Daily dose

(mg/kg)

No.

of patients

Mean

wt (kg) ± SD

AUC_0–∞

(h·μg/ml)

t_1/2 (h)

CL (ml/h/kg)

0.5

15

38.6 ± 19.59

25.9 ± 2.8

12.6 ± 0.7

22.7 ± 2.6

1.0

16

45.9 ± 32.91

52.4 ± 4.7

12.5 ± 1.1

21.8 ± 2.4

1.5

13

36.7 ± 18.33

106.8 ± 16.7

12.8 ± 1.1

17.4 ± 3.2

2.0

11

29.5 ± 11.98

113.8 ± 16.0

13.2 ± 2.0

20.8 ± 2.9

3.0

9

30.9 ± 13.18

206.6 ± 23.0

11.7 ± 0.6

15.9 ± 1.6

4.0

7

28.0 ± 11.61

247.1 ± 23.8

11.6 ± 1.0

17.4 ± 2.5