Parameter | Lapatinib | NSC278329 | NSC642003 | NSC718305 |
Human Intestinal Absorption Blood-Brain Barrier Caco-2 Permeability P-glycoprotein Substrate Renal organic cation transporter CYP450 2C9 Substrate CYP450 2D6 Substrate CYP450 3A4 Substrate CYP450 1A2 Inhibitor CYP450 2C9 Inhibitor CYP450 2D6 Inhibitor CYP450 2C19 Inhibitor CYP450 3A4 Inhibitor CYP450 Inhibitory Promiscuity hERG inhibition I hERG inhibition II AMES Toxicity Carcinogensa | HIA+ BBB+ Caco2- Substrate Non-inhibitor Non-substrate Non-substrate Substrate Non-inhibitor Non-inhibitor Non-inhibitor Non-inhibitor Inhibitor High Inhibitor Inhibitor Non-toxic Non-carcinogens | HIA+ BBB- Caco2- Substrate Non-inhibitor Non-substrate Non-substrate Substrate Non-inhibitor Non-inhibitor Non-inhibitor Inhibitor Inhibitor Low Non-inhibitor Non-inhibitor Non-toxic Non-carcinogens | HIA+ BBB- Caco2- Non-substrate Non-inhibitor Non-substrate Non-substrate Substrate Non-inhibitor Non-inhibitor Non-inhibitor Inhibitor Non-inhibitor High Non-inhibitor Non-inhibitor Non-toxic Carcinogens | HIA+ BBB+ Caco2- Non-substrate Non-inhibitor Non-substrate Non-substrate Substrate Non-inhibitor Non-inhibitor Non-inhibitor Non-inhibitor Inhibitor Low Non-inhibitor Non-inhibitor Non-toxic Non-carcinogens |