Parameter

Lapatinib

NSC278329

NSC642003

NSC718305

Human Intestinal Absorption

Blood-Brain Barrier

Caco-2 Permeability

P-glycoprotein Substrate

Renal organic cation transporter

CYP450 2C9 Substrate

CYP450 2D6 Substrate

CYP450 3A4 Substrate

CYP450 1A2 Inhibitor

CYP450 2C9 Inhibitor

CYP450 2D6 Inhibitor

CYP450 2C19 Inhibitor

CYP450 3A4 Inhibitor

CYP450 Inhibitory Promiscuity

hERG inhibition I

hERG inhibition II

AMES Toxicity

Carcinogensa

HIA+

BBB+

Caco2-

Substrate

Non-inhibitor

Non-substrate

Non-substrate

Substrate

Non-inhibitor

Non-inhibitor

Non-inhibitor

Non-inhibitor

Inhibitor

High

Inhibitor

Inhibitor

Non-toxic

Non-carcinogens

HIA+

BBB-

Caco2-

Substrate

Non-inhibitor

Non-substrate

Non-substrate

Substrate

Non-inhibitor

Non-inhibitor

Non-inhibitor

Inhibitor

Inhibitor

Low

Non-inhibitor

Non-inhibitor

Non-toxic

Non-carcinogens

HIA+

BBB-

Caco2-

Non-substrate

Non-inhibitor

Non-substrate

Non-substrate

Substrate

Non-inhibitor

Non-inhibitor

Non-inhibitor

Inhibitor

Non-inhibitor

High

Non-inhibitor

Non-inhibitor

Non-toxic

Carcinogens

HIA+

BBB+

Caco2-

Non-substrate

Non-inhibitor

Non-substrate

Non-substrate

Substrate

Non-inhibitor

Non-inhibitor

Non-inhibitor

Non-inhibitor

Inhibitor

Low

Non-inhibitor

Non-inhibitor

Non-toxic

Non-carcinogens