All patients

FOLFOX + dipeptide glutamine (%)

FOLFOX (%)

P

After 2 cycles

Grade 0

Grade 1-2

Grade 3-4

55 (91.7)

5 (8.3)

0 (0)

47 (78.3)

12 (20)

1 (1.7)

0.05

After 4 cycles

Grade 0

Grade 1-2

Grade 3-4

48 (80)

8 (13.3)

4 (6.7)

35 (85.3%)

16 (26.7)

9 (15)

0.02

After 6 cycles

Grade 0

Grade 1-2

Grade 3-4

40 (66.7)

12 (20)

8 (13.3)

24 (40)

18 (30)

20 (33.3)

0.04