Variable

baseline

The 1st course

The 2nd course

The 3rd course

P value

CI

Acute asthma attack in past year―no. (%)

91 (29.4)

81 (26.1)

67 (21.6)

71 (22.9)

0.000###

21.563

Days for asthma-related symptoms in last 12 months―(means ± SD)

106.49 ± 142.83

66.22 ± 110.68

42.49 ± 81.51

42.31 ± 88.82

0.000###

Pulmonary function test

1.85 ± 0.94

1.73 ± 0.67

1.92 ± 1.51

1.80 ± 0.98

0.233

81.68 ± 19.06

82.76 ± 14.89

83.37 ± 14.60

79.50 ± 19.17

0.221

Asthma-related health care in last 12 months―no. (%)

≥1 Admit to A & E

20 (22)

10 (11)

10 (11)

6 (6.6)

0.014#

10.65

≥1 Hospitalization

14 (15.4)

7 (7.7)

4 (4.4)

3 (3.3)

0.010#

11.452

≥1 Outpatient visit

74 (81.3)

44 (48.4)

49 (54.4)

50 (55.6)

0.000###

24.264

≥1 Prescription

79 (86.8)

76 (83.5)

58 (63.7)

62 (68.1)

0.000###

18.926

≥1 By own medication

12 (13.2)

12 (13.2)

6 (6.6)

7 (7.7)

.0296#

3.700

≥1Not to be proceed

9 (9.9)

10 (11)

10 (11)

8 (8.8)

.0331#

0.954

The frequency of bronchodilator during asthma attack―no. (%)

More than twice per day

24 (27.3)

15 (17)

12 (13.6)

37 (42)

63.257

Once to twice per day

33 (39.3)

28 (33.3)

13 (15.5)

10 (11.9)

Twice to three times per week

9 (47.4)

3 (15.8)

6 (31.6)

1 (5.3)

Less than once per week

15 (26.3)

13 (22.8)

19 (33.3)

10 (17.5)

Never

9 (8.9)

29 (28.7)

28 (37.6)

25 (24.8)