Variable

Baseline

Week 2

Week 4

Week 6

Acetylcholine (nmol/L)

Placebo

2.45 ± 0.20

2.44 ± 0.21

2.39 ± 0.18

2.43 ± 0.19

Supplement

2.20 ± 0.15

2.42 ± 0.12

2.29 ± 0.06

2.49 ± 0.18

BDNF (ng/mL)

Placebo

36.5 ± 4.2

37.3 ± 5.0

37.6 ± 3.4

38.0 ± 3.7

Supplement

34.7 ± 4.0

36.4 ± 4.9

32.1 ± 3.4

41.1 ± 2.8 **

irisin (ng/mL)

Placebo

29.9 ± 0.6

30.0 ± 0.9

29.6 ± 1.2

29.7 ± 1.1

Supplement

29.6 ± 0.6

30.1 ± 0.7

29.0 ± 0.4

30.8 ± 0.5**

Melatonin (pg/mL)

Placebo

1029.1 ± 13.1

1033.5 ± 5.7

1036.2 ± 8.5

1032.2 ± 15.9

Supplement

1051.7 ± 7.0

1049.5 ± 3.7

1036.5 ± 8.9

1057.3 ± 2.4**