circGPHN | Modulate transcription | Neuroinflammation, neuronal cell apoptosis, Predict higher AD risk, target GPHN. | CSF | Yes | [54] |
circ_0131235 | Target IGF2-receptor. | Brain | Yes | [98] | |
NF1-419 | Neuroinflammation, reduction of inflammatory mediators (IL-6, IFN-β). | SAMP8 mice | [93] | ||
circKCNN2 | Clinical severity and Braak neuropathologic staging. | Brain | [53] | ||
circPAR1 | Predict higher AD risk. | CSF | Yes | [54] | |
circHAUS4 | Predict lower AD risk. | CSF | Yes | [54] | |
circKIF18B | Predict lower AD risk. | CSF | Yes | [54] | |
circTTC39C | Predict lower AD risk. | CSF | Yes | [54] | |
circTRPC6 | Regulate cognitive performance, reduction in Aβ production, Interacts with APP leading to inhibition of its cleavage by g-secretase, Early diagnosis. | Yes | [30] [56] | ||
circNME7 | Regulate neuronal differentiation and development, Early diagnosis. | Yes | [56] | ||
circAPOE | Brain | [54] | |||
circMAN2A1 | Clinical severity and Braak neuropathologic staging. | Brain | [53] [58] | ||
circFMN1 | Clinical severity and Braak neuropathologic staging. | Brain | [53] [58] | ||
circMAP7 | Clinical severity and Braak neuropathologic staging. | Brain | [53] [58] | ||
circTTLL7 | Clinical severity and Braak neuropathologic staging. | Brain | [53] [58] | ||
circPICALM | Clinical severity and Braak neuropathologic staging. | Brain | [53] [58] | ||
circKIAA1586 | hsa-miR-29b, hsa-miR-15a, hsa-miR-101 | Yes | [61] | ||
circ_0007556 | Encoding the new Aβ-175 polypeptide variant called circAβ-a. | [84] | |||
circCwc27 | Pur-α overexpression largely phenocopied circCwc27 Knockdown in preventing Aβ deposition and cognitive decline. | [86] | |||
mmu_circRNA_017963 | Associated with different autophagosome and vesicular transport pathways. | [91] |