Ref

Cases/Sex

Age

Interval to metastasis in years

Cell type

Site of metastasis

Treatment

Outcome

1

3/1M/2F

45 - 64

6 - 8

Clear cell Papillary Clear cell

Right thigh Right atrium & ventricle Bladder

Radical excision Excision TURBT

NR 1 y Died after 6 m NR 3 y

3

1/M

77

10

Clear cell

Prostate

Sunitinib

Marked regression

4

1/F

76

18

Clear cell

Brain

Stereotactic radiation

Died after six years

5

1/F

52

10

Clear cell

Thyroid

Hemithyroidectomy & partial internal jugular vein resection

Had pancreatic metastasis

6

1/M

83

12

Metastatic RCC

Parotid and Cerebellum

Superficial parotidectomy & stereotactic ablation

Free of disease

7

1/M

65

20

Metastatic RCC

Falx (meningeal)

Total removal & radiochemo therapy

In good condition at 4 months

8

1/M

76

7

Clear cell

Perianal lesion

Surgical removal

Has also had a lesion adjacent to the occipital horn of the left lateral ventricle

9

1/F

65

20

Metastatic RCC

Extra-axial Cerebral

Removal of tumor

Had Lung metastasis

10

1/M

61

19

Clear cell

Cerebral* & Thyroid

Total excision and Left hemi throidectomy

Fourteen months after surgery no neurological deficit

11

1/M

63

11

Clear cell

Left Parotid

Left parotidectomy

NR at 4 years

12

1/M

50

3

Metastatic RCC

Thyroid

Total throidectomy

NR

13

1/F

56

11

Metastatic RCC

Thyroid and Parotid

Parotidectomy and resection of thyroid metastasis

NR at 2 years

14

1/F

59

10

Metastatic RCC

Parotid

Superficial parotidectomy

Developed RCC of Left kidney had Radical nephrectomy, now on dialysis NR at 18 months

15

1/M

83

10

Clear cell

Submaxillary gland

Excision of right submaxillary gland

NR at 1 year

16

1/M

77

15

Clear cell

Brain

Partial excision then Gamma knife surgery

Right hemiparesis diappeared, Sensory aphasia continued. Rehabilitated

17

1/M

65

19

Metastatic clear cell

Buccal mucosa

Surgical removal

NR at 6 years

18

1/F

54

16

Metastatic clear cell

choroid plexus

Stereotactic excision surgery

no neurological deficit at 3 weeks

19

1/F

80

9

Clear cell

Thyroid

Hemithyroidectomy

Developed Body and head of the pancreas masses. No further treatment was proposed due to patient’s age and comorbidities

20

1/F

87

19

Metastatic clear cell

Thyroid

Hemithyroidectomy

NR at 28 months

21

1/M

57

4⅟2

RCC

Renal fossa

Surgical removal

Left lung metastasis removed, 9th right rib lesion on bisphosphonates, with a good response so far.

22

28/M 16/F = 44

55 - 71

Median time 7.7 years

41 Clear cell 1 Chromophobe 2 Multiple

Lung, bone, pancreas, mediastinum, adrenal, thyroid, lymph nodes, brain

33 Metastectomy 14 Systemic therapy

Median overall survival 6.1 years

23

29/M 12/M = 41

38 - 76

63 - 234 months

Mostly clear cell

Lung, liver, bone, brain, retroperitoneal lymph node, adrenal

22 Metastectomy 26 Systemic therapy

The 5-year cancer-specific survival rate after recurrence was 73.7%

24

1/M

84

45

Metastatic clear cell

Renal bed, liver, lung

Sudden death 8 hours after biopsy