Genotypes/alleles

Healthy

(n = 100)

Whole diabetics (n = 252)

DR⁻

(n = 130)

DR⁺

(n = 122)

p

OR (95% CI)

Pro12 Ala

Pro/Pro®

72

210 (83.3)

102 (78.5)

108 (88.5)

Pro/Ala

23

38 (15.1)

25 (19.2)

13 (10.7)

0.054

0.491 (0.238 - 1.012)

Ala/Ala

5

4 (1.6)

3 (2.3)

1 (0.8)

0.320

0.315 (0.032 - 3.076)

Pro/Pro vs Pro/Ala - Ala/Ala

28

42 (16.7)

28 (21.5)

14 (11.5)

0.035^*

0.472 (0.235 - 0.947)

Pro allele®

167 (83.5)

458 (90.8)

229 (88.1)

229 (93.9)

Ala allele

33 (16.5)

46 (9.1)

31 (11.9)

15 (6.1)

0.024^*

0.484 (0.254 - 0.920)

C161T

C/C®

57

149 (59.1)

95 (73.1)

61 (50)

C/T

34

85 (33.7)

32 (24.6)

47 (38.5)

0.002^*

2.287 (1.316 - 3.974)

T/T

9

18 (7.1)

3 (2.3)

14 (11.5)

0.003^*

7.268 (2.05 - 26.34)

C/C® vs C/T - T/T

43

103 (40.8)

35 (26.9)

61 (50)

<0.001^*

2.714 (1.605 - 4.591)

C allele®

148 (74)

383 (76)

222 (85.4)

169 (69.3)

T allele

52 (26)

121 (24)

38 (14.6)

75 (30.7)

<0.001^*

2.593 (1.672 - 4.020)