THC
CACAO
Compton scattering and attenuation in the patient
same
same
Number of collected photons
low
×1000
Septal penetration in the collimator
5%
weaker
Noise Amplification in the reconstruction
worse
weak
Noise amplification 
with source to collimator distance
worse
weak
Noise amplification 
with matrix size
worse
weak
Benefiting from a intrinsic spatial resolution improvement
sensitivity
++
Depth of interaction in the detector
weak
worse
Degradation of detector performances due to high count rate
weak
worse
Reconstruction highly regularized at low resolution
weak
worse