Principles No. 1. Waste prevention: it is higher to save you waste than to deal with or smooth waste after its generation. Measure of waste can be described by the following:

$\text{Environmentalfactor}\left(\text{E}\right)=\frac{\text{kg}\text{waste}}{\text{kg}\text{product}}$ , E is the ratio of weight of waste with the weight of product produced during the synthesis process.

Principles No. 2. Atomic economics: is the measurement of the number of atoms present in a final product after the completion of a chemical reaction or synthesis of the original material.

$\%\text{atomiceconomy}=\frac{\text{weightofthedesiredproduct}}{\text{Weightofallreactants}}\times 100$

Principles No. 3 Less unsafe chemical synthesis: wherein viable, synthetic techniques ought to be designed to use and bring materials with very little toxicity to human health and the environment, which includes opportunity reagents replacing phosgene in urethane synthesis.

Principles No. 4 Layout more secures chemical substances: chemical merchandise must be designed to affect their favored function whilst minimizing their toxicity.

Principles No. 5. More secure solvents and excipients: the use of excipients (e.g solvents, separators, etc.) has to be as needless and harmless as feasible at some stage in use, including the use of supercritical CO₂ as an innocent solvent.

Principles No. 6. Strength efficiency concept: the energy necessities of chemical methods ought to be recognized with reference to their environmental and economic effects and ought to be minimized.

Principles No. 7. Reduce derivatives: unnecessary derivatization (use of blockading groups, protection/deprotection, and transient change of physical/chemical tactics) need to be minimized or averted, due to the fact such steps require additional reagents and can generate waste.

Principles No. 8. Catalysis: catalytic reagents (as selectively possible) are higher than stoichiometric reagents.

Principles No. 9. Damage design: chemical products must be designed in such a way that they decompose into a non-hazardous environment at the end of operation and do not remain in the environment.

Principles No. 10. Naturally safer accident prevention chemicals: substances and forms of substances used in a chemical process should be selected in such a way as to minimize the possibility of chemical accidents, including emissions, explosions and fires [1] [2] [4] .

Principles No. 11. Real-time pollution prevention analysis: analytical methods need to be further developed to allow real-time monitoring and control of the process before hazardous substances are generated.