Pre-DBS

1-year after DBS

p value

5-year after DBS

p value

UPDRS III motor score (total)

19.6 ± 8.4 (med-on)

15.6 ± 6.6 (med-on)

< 0.001

18.4 ± 8.2 (med-on)

0.41

41.5 ± 12.7 (med-off)

Tremor (item 20 - 21)

1.0 ± 1.4 (med-on)

0.6 ± 0.9 (med-on)

0.08

0.3 ± 0.8 (med-on)

0.008

4.6 ± 5.4 (med-off)

Rigidity (item 22)

4.5 ± 3.0 (med-on)

2.3 ± 2.0 (med-on)

<0.001

1.8 ± 1.8 (med-on)

<0.001

8.8 ± 3.6 (med-off)

Bradykinesia (item 23 - 26)

7.8 ± 3.3 (med-on)

6.1 ± 3.3 (med-on)

0.02

5.5 ± 4.1 (med-on)

0.004

14.0 ± 4.6 (med-off)

Speech (item 18)

0.9 ± 0.4 (med-on)

0.9 ± 0.4 (med-on)

0.91

1.6 ± 0.7 (med-on)

<0.001

1.3 ± 0.7 (med-off)

Gait (item 29)

0.7 ± 0.6 (med-on)

0.9 ± 0.6 (med-on)

0.12

1.8 ± 1.0 (med-on)

< 0.001

2.3 ± 1.1 (med-off)

Postural stability (item 30)

1.2 ± 0.6 (med-on)

1.3 ± 0.6 (med-on)

0.6

2.0 ± 0.9 (med-on)

<0.001

2.1 ± 0.9 (med-off)

Dyskinesia (item 32 - 35)

2.0 ± 2.0

0.5 ± 0.9

<0.001

0.7 ± 0.8

0.002

Fluctuation (item 36 - 39)

4.0 ± 1.1

0.8 ± 1.4

<0.001

1.2 ± 1.4

<0.001

Medication (LEDD (mg))

600 ± 250

222 ± 174

<0.001

289 ± 171

<0.001