| Variable | n (Cases/ Controls) | PP vs. AA | AP vs. AA | PP+AP vs. AA | PP vs. AP+AA | P vs. A | |||||
| OR (95% CI) | Ph/I2 (%) | OR (95% CI) | Ph/I2 (%) | OR (95% CI) | Ph/I2 (%) | OR (95% CI) | Ph/I2 (%) | OR (95% CI) | Ph/I2 (%) | ||
| Overall | 43 (10610/13645) | 1.17 (0.98 - 1.40) | 0.000/77.6 | 1.17 (1.04 - 1.31) | 0.000/66.2 | 1.17 (1.04 - 1.32) | 0.000/73.8 | 1.01 (0.93 - 1.09) | 0.069/25.6 | 1.09 (1.00 - 1.18) | 0.000/78.0 |
| Ethnicity | |||||||||||
| Asian | 27 (5187/8340) | 119 (0.99 - 1.44) | 0.000/75.2 | 1.13 (1.02 - 1.25) | 0.000/46.2 | 1.16 (1.03 - 1.30) | 0.000/64.8 | 1.09 (0.94 - 1.26) | 0.000/70.5 | 1.10 (1.00 - 1.20) | 0.000/75.9 |
| Caucasian | 11 (3931/3645) | 1.02(0.75 - 1.37) | 0.176/28.2 | 1.04 (0.75 - 1.44) | 0.000/73.0 | 1.03 (0.79 - 1.33) | 0.002/64.6 | 0.96 (0.70 - 1.33) | 0.042/47.1 | 1.01 (0.89 - 1.14) | 0.231/22.3 |
| Mixed | 3 (653/851) | - | - | - | - | - | - | - | - | - |
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| Source of control | |||||||||||
| HB | 32 (8570/10172) | 1.08 (0.93 - 1.26) | 0.000/56.9 | 1.12 (1.00 - 1.25) | 0.001/51.0 | 1.11 (0.99 - 1.26) | 0.000/57.4 | 1.00 (0.88 - 1.12) | 0.002/47.4 | 1.04 (0.96 - 1.12) | 0.000/56.4 |
| PB | 10 (1748/3257) | 1.39 (0.88 - 2.19) | 0.000/80.9 | 1.12 (0.86 - 1.46) | 0.003/63.7 | 1.18 (0.90 - 1.54) | 0.000/71.5 | 1.33 (0.90 - 1.95) | 0.000/80.7 | 1.20 (0.96 - 1.49) | 0.000/81.4 |
| Type of control |
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| Healthy | 28 (7357/9387) | 1.19 (0.97 - 1.47) | 0.000/74.1 | 1.13 (1.01 - 1.28) | 0.001/51.6 | 1.15 (1.01 - 1.30) | 0.000/62.9 | 1.10 (0.93 - 1.30) | 0.000/72.0 | 1.10 (1.00 - 1.21) | 0.000/73.6 |
| Non-gastric cancer | 15 (3253/4258) | 1.10 (0.90 - 1.35) | 0.066/38.3 | 1.10 (0.91 - 1.32) | 0.004/56.3 | 1.08 (0.91 - 1.29) | 0.004/56.8 | 1.02 (0.86 - 1.21) | 0.144/28.5 | 1.04 (0.94 - 1.15) | 0.071/37.5 |
| H-pylori | 5 (1962/2082) |
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| Positive |
| 1.36 (0.97 - 1.91) | 0.252/25.4 | 1.10 (0.88 - 1.36) | 0.548/0.0 | 1.15 (0.93 - 1.41) | 0.398/1.5 | 1.22 (0.97 - 1.54) | 0.372/6.1 | 1.15 (0.99 - 1.33) | 0.326/13.8 |
| Negative |
| 1.12 (0.71 - 1.75) | 0.469/0.0 | 0.93 (0.65 - 1.32) | 0.507/0.0 | 0.96 (0.67 - 1.38) | 0.353/9.3 | 1.20 (0.86 - 1.68) | 0.735/0.0 | 1.04 (0.82 - 1.32) | 0.286/20.2 |
| Gendering | 6 (982/1455) |
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| Male |
| 1.13 (0.6 - 1.95) | 0.108/50.5 | 1.15 (0.85 - 1.55) | 0.574/0.0 | 1.13 (0.84 - 1.53) | 0.355/7.6 | 1.10 (0.68 - 1.78) | 0.011/66.2 | 1.07 (0.83 - 1.39) | 0.119/48.8 |
| Female |
| 1.67 (0.91 - 3.04) | 0.248/27.3 | 1.43 (0.99 - 2.05) | 0.846/0.0 | 1.48 (1.04 - 2.08) | 0.676/0.0 | 1.47 (0.78 - 2.78) | 0.317/14.9 | 1.32 (1.03 - 1.70) | 0.305/17.3 |
| Tumor Location | 7 (1412/2548) |
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| Cardia |
| 1.23 (0.67 - 2.26) | 0.066/49.2 | 1.07 (0.72 - 1.59) | 0.065/49.4 | 1.10 (0.72 - 1.69) | 0.017/61.1 | 1.05 (0.58 - 1.89) | 0.022/59.4 | 1.06 (0.75 - 1.49) | 0.002/70.6 |
| Non-cardia |
| 1.00 (0.72 - 1.38) | 0.208/28.9 | 1.16 (0.94 - 1.45) | 0.224/26.8 | 1.12 (0.90 - 1.40) | 0.154/35.9 | 0.93 (0.74 - 1.16) | 0.524/0.0 | 1.03 (0.88 - 1.21) | 0.138/38.2 |
| Histologicsubtype | 8 (1378/1605) |
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| Intestinal type |
| 1.12 (0.69 - 1.83) | 0.01/62.3 | 0.90 (0.64 - 1.26) | 0.026/56.1 | 0.94 (0.67 - 1.33) | 0.008/63.5 | 1.27 (0.84 - 1.93) | 0.035/53.6 | 1.03 (0.80 - 1.33) | 0.004/66.8 |
| Diffuse type |
| 1.33 (0.87 - 2.03) | 0.095/42.4 | 1.10 (0.85 - 1.41) | 0.305/15.8 | 1.15 (0.91 - 1.44) | 0.318/14.3 | 1.23 (0.84 - 1.80) | 0.051/50.0 | 1.13 (0.92 - 1.38) | 0.070/46.5 |
| Sensitivity analysis | |||||||||||
| HWE and Quality score > 12 | |||||||||||
| Overall | 16 (5513/7792) | 1.08 (0.86 - 1.36) | 0.000/68.5 | 1.06 (0.94 - 1.19) | 0.049/40.1 | 1.07 (0.93 - 1.23) | 0.001/59.1 | 1.04 (0.87 - 1.24) | 0.001/60.2 | 1.04 (0.94 - 1.16) | 0.000/69.5 |
| Ethnicity | |||||||||||
| Asian | 10 (3017/4643) | 1.13 (0.84 - 1.52) | 0.000/80.0 | 1.05 (0.90 - 1.23) | 0.033/52.2 | 1.08 (0.90 - 1.30) | 0.000/71.9 | 1.10 (0.88 - 1.36) | 0.000/72.1 | 1.07 (0.92 - 1.23) | 0.000/80.4 |
| Caucasian | 4 (634/1874) | 0.93 (0.63 - 1.35) | 0.374/3.7 | 1.01 (0.76 - 1.34) | 0.132/46.6 | 0.99 (0.75 - 1.31) | 0.116/49.3 | 0.92 (0.64 - 1.30) | 0.488/0.0 | 0.98 (0.81 - 1.20) | 0.167/40.8 |
| Source of control | |||||||||||
| HB | 10 (4122/5068) | 1.13 (0.89 - 1.44) | 0.012/57.2 | 1.05 (0.94 - 1.17) | 0.326/12.7 | 1.07 (0.93 - 1.23) | 0.076/42.3 | 1.06 (0.87 - 1.30) | 0.019/54.8 | 1.04 (0.93 - 1.17) | 0.007/60.6 |
| PB | 6 (1391/2724) | 1.03 (0.63 - 1.69) | 0.000/79.5 | 1.07 (0.81 - 1.42) | 0.012/65.8 | 1.08 (0.79 - 1.49) | 0.001/76.2 | 1.00 (0.71 - 1.42) | 0.005/69.9 | 1.06 (0.83 - 1.34) | 0.000/80.7 |
| Type of control |
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| Healthy | 11 (4574/6218) | 1.04 (0.80 - 1.36) | 0.000/72.5 | 1.06 (0.92 - 1.23) | 0.030/49.7 | 1.06 (0.90 - 1.25) | 0.002/63.4 | 1.00 (0.81 - 1.23) | 0.001/66.8 | 1.03 (0.91 - 1.17) | 0.000/72.4 |
| Non-gastric cancer | 5 (939/1574) | 1.26 (0.85 - 1.88) | 0.170/37.7 | 1.09 (0.88 - 1.35) | 0.331/12.9 | 1.09 (0.82 - 1.45) | 0.097/49.1 | 1.33 (1.07 - 1.64) | 0.427/0.0 | 1.08 (0.86 - 1.35) | 0.054/57.0 |
| Egger’s test | |||||||||||
| PE |
| 0.627 |
| 0.369 |
| 0.317 |
| 0.419 |
| 0.739 |
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