Treatment

Immunotherapy

Immunotherapy + Chemotherapy

Immunotherapy (c-MET mutation- positive)

c-MET mutations

EFGR mutations

ALK rearrangement

RET

mutations

Chemotherapy (ORR)

PD-1: p = 0.04

PD-L1: p = 0.016

PD-1: p = 0.0001

PD-L1: p = 0.0002

PD-1: p = 0.0018

PD-L1: N.A.

p = 0.0005

p < 0.0001

p = 0.0001

p = 0.0001

Chemotherapy (PFS)

PD-1: p = 0.02

PD-L1: p = 0.03

PD-1: p = 0.0012

PD-L1: p = 0.0008

PD-1: p = 1.15

PD-L1: N.A.

p = 0.0002

p = 0.0007

p = 0.0056

p = 0.04

c-MET mutations (ORR)

PD-1: p = 0.12

PD-L1: p = 0.28

PD-1: p = 0.25

PD-L1: p = 0.47

N.A

N.A.

N.A.

N.A.

N.A.

c-MET mutations

(PFS)

PD-1: p = 0.66

PD-L1: p = 0.79

PD-1: p = 0.13

PD-L1: p = 0.34

N.A

N.A.

N.A

N.A.

N.A.

Immunotherapy (c-MET mutation- positive) (ORR)

PD-1: p = 0.15

PD-1: p = 0.01

N.A.

PD-1: p = 0.07

N.A.

N.A.

N.A

Immunotherapy (c-MET mutation- positive) (PFS)

PD-1: p = 0.27

PD-1: p = 0.07

N.A.

PD-1: p = 0.07

N.A.

N.A.

N.A.