Authors | Study Design | Sample Size (N) | Instrument | Main Finding | Potential Clinical Application |
Oberbaum et al. [8] | Randomized, placebo-controlled, double blind | N = 32 | WHO grading for mucositis | Traumeel S reduces duration and severity of stomatitis | Efficacy in treating stomatitis in patients with chemotherapy |
Sencer et al. [20] | Randomized, placebo-controlled, double blind | N = 195 | Three-grade modified Walsh scale for mucositis; WHO Oral toxicity Scale | No difference in treatment of stomatitis | Unknown |
Porozov et al. [29] | In vitro | N = 24 | IL-1B, TNFa and IL-8 | Traumeel lowers levels of IL-1B, TNF-a and IL-8 | Inhibit chronic inflammation |
Pilat et al. [7] | Randomized, placebo-controlled, double blind | N = 40 | IL-6 and hsCRP | Trammel lowered leukocytosis and neutrocytosis, but not IL-6 and hsCRP | Unknown |
Gonzalez de Vega et al. [6] | Randomized, controlled study | N = 449 | VAS and FAAM scores | No difference in pain improvement in epicondylitis | Alternative therapy for orthopedic injury |
Birnesser et al. [19] | Observational, non-randomized study | N = 184 | Questionnaire with “good” or “very good” response | Trameel S reduces pain and increases mobility in epicondylitis | Alternative therapy for orthopedic injury |
Bohmer et al. [26] | Controlled, double-blind study | N = 102 | Swelling and skin temperature | Trameel S reduces swelling and skin temperature following injury | Efficacy in treating soft tissue injury |
Schneider et al. [5] | Observational cohort study | N = 133 | 3 point scale of pain reporting | No difference in pain improvement following trauma and injuries | Unknown |
Singer et al. [31] | Randomized double blind placebo study | N = 80 | 11-point numerical rating pain score | No difference in pain improvement following orthopedic surgery following Traumeel S administration | Unknown |
Zilinskas et al. [30] | In vitro | N = 43 | Leukocyte count and the Antioxidant capacity of the blood and serum | Increase in antioxidant activity in blood, but increase in leukocyte count in patients with periodontitis following Traumeel S administration | Unknown |