| Hot-plate test | AA-induced writhing test | ||
Groups | Before Administration | After Administration | Difference | Number of writhing within 10 min |
The latency to licking paws (sec) | ||||
Control | 11.8 ± 4.7 | 12.3 ± 4.5 | 0.5 ± 0.6a | 42.5 ± 4.3a |
Aspirin | 11.3 ± 1.2 | 19.0 ± 2.8 | 7.7 ± 3.3c | 17.3 ± 4.1b |
HME 77 | 11.5 ± 3.9 | 12.8 ± 3.5 | 1.3 ± 0.8ab | 35.0 ± 2.4cf |
HME 154 | 12.0 ± 3.9 | 15.7 ± 4.5 | 3.7 ± 1.5ab | 31.0 ± 3.6cde |
HME 308 | 11.2 ± 2.7 | 21.8 ± 6.2 | 10.7 ± 4.4c | 27.2 ± 6.0e |
IMP 0.6 | 10.3 ± 1.2 | 14.0 ± 2.8 | 3.7 ± 2.2ab | 39.7 ± 3.6af |
IMP 1.2 | 10.0 ± 2.5 | 14.5 ± 2.9 | 4.5 ± 1.2b | 35.8 ± 2.6cf |
OST 2.2 | 9.8 ± 1.6 | 14.0 ± 2.6 | 4.2 ± 2.5b | 33.5 ± 6.4cd |
OST 4.4 | 10.3 ± 3.2 | 18.8 ± 5.2 | 8.2 ± 3.6c | 28.3 ± 4.1de |