Hot-plate test

AA-induced writhing test

Groups

Before Administration

After Administration

Difference

Number of writhing within 10 min

The latency to licking paws (sec)

Control

11.8 ± 4.7

12.3 ± 4.5

0.5 ± 0.6a

42.5 ± 4.3a

Aspirin

11.3 ± 1.2

19.0 ± 2.8

7.7 ± 3.3c

17.3 ± 4.1b

HME 77

11.5 ± 3.9

12.8 ± 3.5

1.3 ± 0.8ab

35.0 ± 2.4cf

HME 154

12.0 ± 3.9

15.7 ± 4.5

3.7 ± 1.5ab

31.0 ± 3.6cde

HME 308

11.2 ± 2.7

21.8 ± 6.2

10.7 ± 4.4c

27.2 ± 6.0e

IMP 0.6

10.3 ± 1.2

14.0 ± 2.8

3.7 ± 2.2ab

39.7 ± 3.6af

IMP 1.2

10.0 ± 2.5

14.5 ± 2.9

4.5 ± 1.2b

35.8 ± 2.6cf

OST 2.2

9.8 ± 1.6

14.0 ± 2.6

4.2 ± 2.5b

33.5 ± 6.4cd

OST 4.4

10.3 ± 3.2

18.8 ± 5.2

8.2 ± 3.6c

28.3 ± 4.1de