Formulation

Molar ratio

Liposomea)

Lipoplex of siRNAa,b)

Size (nm)

ζ-potential (mV)

Size (nm)

ζ-potential (mV)

DOTAP/Chol

DOTAP/DOPE

OH-Chol/DOPE

OH-C-Chol/DOPE

1/1

1/1

3/2

3/2

101.2 ± 2.5

116.2 ± 2.9

126.0 ± 2.9

120.5 ± 2.7

56.0 ± 1.0

49.7 ± 0.6

52.8 ± 0.9

47.5 ± 1.8

189.5 ± 5.0

189.0 ± 6.0

220.1 ± 1.9

195.3 ± 5.2

41.7 ± 0.4

44.4 ± 0.8

46.7 ± 0.8

46.1 ± 1.8