Formulation

Particle size (nm)^a)

ζ-potential (mV)^a)

Entrapment efficiency (%)^a)

Before

After

Before

After

PM

221.7 ± 186.4

203.7 ± 194.3

−21.3 ± 4.5

0.5 ± 1.7

66.1 ± 4.0

HNP-P5

107.7 ± 9.4

103.3 ± 7.7

−13.4 ± 0.7

2.2 ± 3.4

44.5 ± 2.4

HNP-P50

65.4 ± 5.5

54.6 ± 4.7

−16.9 ± 1.3

2.5 ± 2.3

56.2 ± 14.3