[52] | rat diabetes induced by STZ injection | simvastatin | restored Cx43 expression and integrity of gap junctions in hearts |
| apoptosis of cardiomyocytes decreased | |||||
[56] | LV hypertrophy in SHR | atorvastatin | Cx43 expression reduced, gap junction remodeling suppressed in LV |
| LV hypertrophy ameliorated | |||||
[57] | LV hypertrophy induced by abdominal aortic constriction in rats | atorvastatin | gap junction (Cx43) remodeling suppressed |
| LV hypertrophy ameliorated | |||||
[58] | Ang II induced hypertrophy jn primarily cultured rat atrial myocytes | atorvastatin | expression of Cx40 increased, gap junction remodeling suppressed |
| hypertrophy of atrial myocytes ameliorated | |||||
Part 3: Modulation of Cxs/gap junctions by statins against tumors | ||||||||||
[66] | ras-transformed rat liver epithelial cells | lovastatin | GJIC enhanced |
| transformation and tumorigenesis of the cells inhibited | |||||
rat hepatic tumors induced by ras-transformed liver epithelial cells | lovastatin | ND |
| tumor size decreased | ||||||
[67] [68] | MCF-7 breast cancer cells | lovastatin | GJIC enhanced |
| proliferation inhibited, cell cycle arrested, differentiation induced | |||||
[69] | adenocarcinoma cell mixture containing WT (90%) and HSV-tk transduced (10%) cells | lovastatin | GJIC enhanced |
| BSE enhanced and tumor cell killing increased when co-administered with GCV | |||||
mice subcutaneous tumors induced by adenocarcinoma cell mixture | lovastatin | ND |
| tumor-free survival rate of the mice increased when co-administered with GCV | ||||||
[70] | MLTC-1 | simvastatin | Cx43 expression had no change but phosphorylation decreased and membrane localization increased, GJIC enhanced |
| cytotoxicity of etoposide increased | |||||