Activity

IV (LD)

IV (SD)

SC

Description

Medical Consultation (minutes per consultation)

Specialist Consultation

42

N/A

42

Average duration across study sites for each new patient consultation with a specialist.

Medical Officer Consultation

N/A

24

24

Average duration across study sites for each follow-up consultation by a medical officer.

CDR Pharmacy Activities (minutes per infusion prepared)

Worksheet and component preparation

13

13

N/A

The duration is an average across study sites for each infusion prepared.

Isolator room preparation and cleaning

1

1

N/A

The duration is an average across study sites. The total time spent on the task by all pharmacy staff in the isolator room was aggregated, then apportioned to each infusion prepared.

Infusion preparation

22.5

22.5

N/A

QA and checking

7

7

N/A

The duration is an average across study sites.

Total CDR pharmacy time

43.5

43.5

N/A

Drug Administration Activities (minutes per treatment)

Preparation activities

9.3

9.3

5.7

Includes tasks for drug collection, drug preparation and patient preparation. Average of estimated duration across study sites, then apportioned to each patient under a nurse’s care.

Administration of loading dose

20

13.3

6

IV dosing duration is based on the manufacturer’s prescribing information [18] . SC dosing duration was estimated by nurses from Penang General Hospital. Total dosing time is apportioned to each patient under a nurse’s care.

Post-administration activities

14.2

14.2

14.2

Includes tasks for saline flushing, IV device removal, patient monitoring, and scheduling the next appointments. IV duration was an average of estimated duration across study sites, apportioned to each patient under a nurse’s care.

SC duration is assumed to be equal to IV.

Total nurse time

43.5

36.8

31.9