Subgroup |
| N | BRCA1/2 cases versus population-based cases | BRCA1/2 cases versus hospital-based cases | |||
Unadjusted | Adjusted1 | Unadjusted | Adjusted1 | ||||
OR (95%-CI) | OR (95%-CI) | OR (95%-CI) | OR (95%-CI) | ||||
| Cases stratified by tumour diameter | ||||||
BRCA 1 | ≤2 cm | 171 | 1.7 (1.2 - 2.3) | 1.6 (1.2 - 2.3)* | 2.7 (1.9 - 3.7) | 2.9 (2.0 - 4.2)* | |
>2 cm | 156 | 0.7 (0.5 - 0.9) | 0.8 (0.6 - 1.1) | 0.9 (0.6 - 1.2) | 1.5 (1.0 - 2.2)* | ||
BRCA 2 | ≤2 cm | 51 | 2.0 (1.1 - 3.4) | 1.9 (1.1 - 3.3)* | 3.1 (1.8 - 5.5) | 3.1 (1.7 - 5.6)* | |
>2 cm | 47 | 1.2 (0.6 - 2.1) | 1.3 (0.7 - 2.4) | 1.5 (0.8 - 2.7) | 1.9 (1.0 - 3.7) | ||
| Cases stratified by age at breast cancer diagnosis | ||||||
BRCA 1 | <35 | 107 | 0.8 (0.5 - 1.3) | 0.8 (0.5 - 1.4) | 1.0 (0.7 - 1.6) | 1.4 (0.8 - 2.4) | |
35 - 52 | 205 | 1.4 (1.1 - 1.9) | 1.5 (1.1 - 2.0)* | 1.8 (1.4 - 2.4) | 2.5 (1.8 - 3.5)* | ||
>52 | 42 | 1.3 (0.7 - 2.4) | 1.2 (0.6 - 2.3) | 1.6 (0.9 - 2.9) | 1.8 (0.9 - 3.7) | ||
BRCA 2 | <35 | 16 | 1.0 (0.4 - 2.8) | 1.0 (0.3 - 3.0) | 1.3 (0.5 - 3.7) | 1.3 (0.4 - 4.1) | |
35 - 52 | 76 | 2.0 (1.3 - 3.2) | 1.9 (1.1 - 3.1)* | 2.6 (1.6 - 4.1) | 2.6 (1.5 - 4.4)* | ||
>52 | 20 | 2.3 (0.9 - 5.6) | 2.4 (0.9 - 6.8) | 2.7 (1.1 - 6.7) | 4.4 (1.5 -12.9)* | ||
| Cases stratified by age at breast cancer diagnosis and tumour diameter | ||||||
BRCA 1(only grade 3 tumours included | <35 | ≤2 cm | 27 | 2.1 (0.8 - 5.9) | x2 | 1.8 (0.7 - 4.9) | x2 |
>2 cm | 34 | 0.4 (0.2 - 0.9) | 0.5 (0.2 - 1.4) | 0.7 (0.3 - 1.7) | 1.4 (0.5 - 4.0) | ||
35 - 52 | ≤2 cm | 63 | 2.5 (1.5 - 4.4) | 2.8 (1.6 - 4.8)* | 3.5 (2.0 - 6.2) | 5.1 (2.7 - 9.8)* | |
>2 cm | 54 | 1.2 (0.7 - 2.1) | 1.5 (0.8 - 2.6) | 1.1 (0.6 - 2.0) | 1.9 (1.0 - 3.7) | ||
>52 | ≤2 cm | 11 | 0.6 (0.1 - 2.7) | 0.6 (0.1 - 2.9) | 0.6 (0.1 - 2.7) | 0.9 (0.1 - 5.0) | |
>2 cm | 12 | 0.8 (0.2 - 2.4) | 0.9 (0.3 - 2.9) | 0.9 (0.3 - 2.8) | 2.4 (0.6 - 9.3) | ||
BRCA 22 |
| ||||||
| Cases stratified by year of diagnosis and tumour diameter | ||||||
BRCA 1 (only grade 3 tumours included | ≤1995 | ≤2 cm | 53 | 0.8 (0.4 - 1.6) | x2 | 0.9 (0.4 - 1.7) | x2 |
>2 cm | 37 | 0.5 (0.3 - 1.1) | 0.8 (0.4 - 1.8) | 1.0 (0.5 - 1.9) | 2.4 (1.1 - 5.3)* | ||
>1995 | ≤2 cm | 48 | 5.7 (3.0 - 10.7) | 5.8 (3.0 - 11.2)* | 6.5 (3.4 - 12.6) | 10.3 (4.8 - 22.3)* | |
>2 cm | 63 | 1.0 (0.6 - 1.8) | 1.0 (0.6 - 1.8) | 0.9 (0.5 - 1.6) | 1.5 (0.8 - 2.8) | ||
BRCA 22 |
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