|
| Clinical genetic centers | Reference groups | ||
| BRCA1 | BRCA2 | Population based | Hospital based | |
| Medical centers, patients (N) |
|
|
|
|
| Antoni van Leeuwenhoek hospital | 79 | 30 | NA | 6896 |
| Erasmus MC- Daniel den Hoed Cancer Center | 212 | 44 | NA | NA |
| Leiden University Medical Center | 51 | 36 | NA | NA |
| University Medical Center Utrecht | 24 | 2 | NA | NA |
| Comprehensive Cancer Center South | NA | NA | 13498 | NA |
| Total (N) | 366 | 112 | 13498 | 6896 |
| Diagnosis year (N (%)) |
|
|
|
|
| Range | 1980-2006 | 1981-2006 | 1980-2007 | 1987-2000 |
| 1980-1990 | 110 (30) | 35 (31) | 3860 (28) | 1541 (22) |
| 1991-2000 | 202 (55) | 49 (44) | 5112 (38) | 5355 (78) |
| 2001-2010 | 54 (15) | 28 (25) | 4526 (34) | 0 |
| Age at diagnosis (N (%)) |
|
|
|
|
| Mean age (range) | 41 (19 - 72) | 44 (31 - 81) | 57 (20 - 81) | 55 (23 - 81) |
| <35 years | 108 (30) | 16 (14) | 359 (3) | 266 (4) |
| 35 - 52 years | 211 (58) | 76 (68) | 4782 (35) | 2998 (43) |
| >52 years | 47 (12) | 20 (18) | 8357 (62) | 3632 (53) |
| Differentiation grade (N (%)) |
|
|
|
|
| Grade 1 | 1 (<1) | 4 (6) | 1523 (22) | 1053 (19) |
| Grade 2 | 29 (12) | 17 (25) | 3091 (46) | 2724 (50) |
| Grade 3 | 210 (88) | 46 (69) | 2168 (32) | 1727 (31) |
| Missing | 126 | 45 | 6716 | 1392 |
| Tumor diameter (N (%)) |
|
|
|
|
| ≤2 cm | 172 (52) | 51 (52) | 7064 (54) | 3529 (52) |
| >2 cm | 157 (48) | 47 (48) | 6087 (46) | 3320 (48) |
| Missing | 37 | 14 | 347 | 47 |
| Estrogen receptor (N (%)) |
|
|
|
|
| Negative | 189 (77) | 19 (25) | 2196 (23) | 1050 (23) |
| Positive | 56 (23) | 57 (75) | 7443 (77) | 3536 (77) |
| Missing | 121 | 36 | 3859 | 2310 |
| Nodal status (N (%)) |
|
|
|
|
| Negative | 225 (66) | 49 (47) | 6624 (55) | 3143 (48) |
| Positive | 115 (34) | 56 (53) | 5348 (45) | 3435 (52) |
| Missing | 26 | 7 | 1526 | 318 |