| 1 | Studying small animal more conveniently | Replacement, Reduction, Refinement |
| Similar physiology and biology to humans | ||
| Easy to handle and manage its environment | ||
| High sample number and reproducibility of the study | ||
| Shorter life span and follow up time | ||
| 2 | Production of regenerative medicine products | Preparation of graft and Scaffold |
| Production of growth factors by xenograft preparation | ||
| Inducing defects for study | ||
| Exact sampling | ||
| 3 | More precise replacement | Scaffold attachment |
| Proper vascularization technique | ||
| Efficient nerve and vascular transplantation during major surgeries |