| Downregulated Genes Associated with Breast Cancer Cell Proliferation in the Genes Only in Sirtuin Signaling | ||||||
| Gene ID | Gene Name | Log ratio | Location | Family | Association | Data Set |
| BECN1 | Beclin 1 | −6 | Cytoplasm | Other | Suppresses breast cancer cell growth | Down reg. |
| CXCL8 | C-X-C motif chemokine ligand 8 | −4.7 | Extracellular Space | Cytokine | Cell proliferation and inhibit apoptosis | Down reg. |
| DUSP6 | Dual specificity | −6.7 | Cytoplasm | Phosphate | Tumor suppressor | Down reg. |
| E2F1 | E2F transcription factor 1 | −7.6 | Nucleus | Transcription regulator | Increase malignancy stage of breast tumors | Down reg. |
| ESRRA | Estrogen Related receptor alpha | −5.3 | Nucleus | Transcription receptor | Increase rate of recurrence | Down reg. |
| FOXO1 | Forkhead box O1 | −1.7 | Nucleus | Transcription receptor | Suppress metastatic | Down reg. |
| GLS | Glutaminase | −6.5 | Cytoplasm | Enzyme | protumorigenic | Down reg. |
| GSK3B | Glycogen synthase kinase 3 beta | −4.8 | Nucleus | Kinase | Tumor suppressor for mammary tumors | Down reg. |
| H1-2 | H1-2. Linker Histone | −7.6 | Nucleus | Other |
| Down reg. |
| HIF1A | Hypoxia inducible factor 1 subunit alpha | −4.6 | Nucleus | Transcription receptor | Breast cancer metastasis | Down reg. |
| HSF1 | Heat Shock Transcription Factor 1 | −8.3 | Nucleus | Transcription receptor | Cancer cell survivor | Down reg. |
| IDH2 | Isocitrate dehydrogenase | −5.8 | Cytoplasm | Enzyme |
| Down reg. |
| MAP1LC3A | Microtubule associated protein 1 light chain 3 alpha | −6.8 | Cytoplasm | Other |
| Down reg. |
| MAPK1 | Mitogen-activated protein kinase 1 | −5.9 | Cytoplasm | Kinase | Progression in breast cancer | Down reg. |
| MAPK6 | Mitogen-activated protein kinase 6 | −4 | Cytoplasm | Kinase | Decrease in cell survival | Down reg. |
| MAPK7 | Mitogen-activated protein kinase 7 | −3 | Cytoplasm | Kinase |
| Down reg. |