Marker of nitric oxide production

Assessment point

HIV-1 positive

HIV negative

Community controls

Fe pos (Sgr I)

n = 54

Fe neg (Sgr II)

n = 54

Fe pos

(Sgr III)

Fe neg

(Sgr IV)

(Sgr V)

Category of ARI on

follow up

Category of ARI on follow up

PT

n = 38

non-PT

n = 16

PT

n = 10

non-PT

n = 44

n = 30

n = 50

n = 40

Nitrite (µM)

En

1.1 ± 0.6^‽‡

2.6 ± 0.4^‽

20.2 ± 6.6^#§

12.8 ± 3.5^#

1.3 ± 0.8^‽

5.2 ± 3.8

4.4 ± 2.6

Fu

56.6 ± 16.2*

32.8 ± 13.5*

36.4 ± 10.8*

22.4 ± 5.6*

NA

NA

NA

Citrulline (µM)

En

4.2 ± 2.1^‽‡

8.2 ± 2.6^‽

46.2 ± 19.6^#§

31.8 ± 12.4^#

5.2 ± 3.1^‽

24 ± 7.4

20 ± 8.6

Fu

82.4 ± 10.6*

56.6 ± 12.4*

60.4 ± 8.2*

52.4 ± 8.2*

NA

NA

NA

Neopterin (nM)

En

0.8 ± 0.3^‽‡

1.2 ± 0.6^‽

22.4 ± 3.4^#§

12.1 ± 5.2^#

0.9 ± 0.24^‽

2.6 ± 2.4

6.8 ± 3.4

Fu

19.4 ± 6.6*

14.6 ± 4.4*

38.4 ± 8.2*

28.4 ± 6.4*

NA

NA

NA