PROCESS	GSH	t-PA	PLASM	PAI-1	α2-AP	Ant Def	PA
TED	↓	↓	↓	↑	N	↓	↓
Obesity	↓	↓	↓	↑	N	↓	↓
Hyperinsulinemia	↓	↓	↓	↑	N	↓	↓
Hyperglycemia	↓	↓	↓	↑	N	↓	↓
Insulin resistance	↓	↓	↓	↑	N	↓	↓
Type 2 Diabetes mellitus	↓	↓	↓	↑	N	↓	↓
Alzheimer’s disease.	↓	↓	↓	↑	N-↑	↓	↓ Aβ
Intracerebral BSO	↓	↓	↓	↑	N	↓	↓ Aβ
Systemic BSO	↓	↓	↓	↑	N	↓	↓
Intracerebral DM	↓	↓	↓	↑	N	↓	↓ Aβ
Systemic DM	↓	↓	↓	↑	N	↓	↓
Centennials	↑	Ν	↑	Ν	N	↑	↑