| Study | Active ingredients | Dose form | Number of patients | Main efficacy outcome measures | Efficacy results |
| Eccles & Voelker (2013) | Acetylsalicylic acid, pseudoephedrine | Granules dissolved in water to give flavoured drink | 833 | Subjective scores of pain and objective measure of nasal airflow conductance | Efficacy of combined active ingredients superior to placebo |
| Eccles et al. (2007) | Xylometazoline, ipratropium | Nasal spray | 786 | Subjective scores of runny nose and congestion | Efficacy of combined active ingredients superior to placebo |
| Mizogouchi et al. (2007) | Acetaminophen, doxylamine, succinate, dextromethorphan, ephedrine sulphate | Syrup | 485 | Composite and individual subjective scores of nasal congestion, runny nose, cough, pain relief | Multi-ingredient symptom scores superior to placebo and also individual symptom scores |
| Eccles et al. (2006) | Paracetamol, pseudoephedrine | Tablet | 305 | Subjective scores of pain and objective measure of nasal airflow conductance | Efficacy of combined active ingredients superior to placebo |
| Loose & Winkel (2003) | Acetylsalicylic acid, pseudoephedrine | Granules dissolved in water and capsules | 643 | Subjective scores of pain and congestion | Efficacy of combined active ingredients superior to placebo |