Patient No.

Response to the initial increased dose bortezomib therapy

Successive treatments after the initial increased bortezomib treatment

Treatment duration of the second increased dose bortezomib treatment (months)

1

PD

BDT50 Bor 1.6 mg/m² on Day 1, Dex 20 mg/body on Days 1-2, and Tha 50 mg/body on Days 1-28

4

2

*

BDT50 Bor 1.6 mg/m² on Day 1, Dex 20 mg/body on Days 1-2, and Tha 50 mg/body on Days 1-28

8##

3

SD

-

*

4

SD

#

*

5

SD

#

*

6

SD

-

*

7

SD

BDT50 Bor 1.6 mg/m² on Day 1, Dex 20 mg/body on Days 1-2, and Tha 50 mg/body on Days 1-28

2##

8

SD

BDT50 Bor 1.6 mg/m² on Day 1, Dex 20 mg/body on Days 1-2, and Tha 50 mg/body on Days 1-28

9##

9

*

BDT50 Bor 1.6 mg/m² on Day 1, Dex 20 mg/body on Days 1-2, and Tha 50 mg/body on Days 1-28

7##

10

*

BDT50 Bor 1.6 mg/m² on Day 1, Dex 20 mg/body on Days 1-2, and Tha 50 mg/body on Days 1-28

6

11

PD

BDT50 Bor 1.6 mg/m² on Day 1, Dex 20 mg/body on Days 1-2, and Tha 50 mg/body on Days 1-28

9##

12

PD

BDT50 Bor 1.6 mg/m² on Day 1, Dex 20 mg/body on Days 1-2, and Tha 50 mg/body on Days 1-28

13##

13

*

-

*

14

*

BDT50 Bor 1.6 mg/m² on Day 1, Dex 20 mg/body on Days 1-2, and Tha 50 mg/body on Days 1-28

3

15

PD

BDL15 Bor 1.6 mg/m² on Day 1, Dex 20 mg/m² on Days 1-2, and Len 15 mg/body on Days 1-28

3

16

SD

-

*

17

PD

-

*

18

*

BD Bor 1.6 mg/m² on Day 1 and Dex 20 mg/body on Days 1-2

1

19

SD

#

*

20

PD

#

*

21

*

#

*

22

PD

-

*