Normal saline

Human growth hormone

Octreotide

08:00 hr

15:00 hr

Difference

08:00 hr

15:00 hr

Difference

08:00 hr

15:00 hr

Difference

FPG (mg/dL)

73.9 ± 5.5

71.9 ± 5.7

−2.0 ± 8.8

79.1±7.5

80.6 ± 3.8

1.5 ± 10.2

79.1 ± 6.1

79.9 ± 6.6

0.8 ± 10.0

FSI (μU/mL)

9.0 ± 4.8

7.4 ± 5.0

−1.6 ± 3.3

13.0±7.5

10.3 ± 6.1

−2.7 ± 3.0

11.1 ± 6.6

10.0 ± 5.6

−1.1 ± 2.4

MCRI (ml/min/m²)

643.2 ± 190.2

691.7 ± 166.3

48.5 ± 246.1

669.0±178.5

671.3 ± 203.9

2.3 ± 163.5

645.8 ± 158.5

534.8 ± 155.5^b,c

−111.0 ± 184.9

NEFA (μmol/L)

267.6 ± 66.7

320.2 ± 52.6

52.6 ± 67.3

318.4±56.6^a

410.0 ± 67.1

91.6 ± 72.6

250.6 ± 56.7^c

239.5 ± 60.1^b,c

−11.1 ± 96.3^c†

IGF-1 (ng/mL)

181.5 ± 43.4

186.3 ± 46.1

4.8 ± 37.4

230.9±38.0

225.0 ± 44.4

−5.9 ± 16.3

159.0 ± 34.1^c

153.9 ± 36.6^c

−5.1 ± 22.2

SSPG (mg/dL)

116.8 ± 33.6^a

150.4 ± 25.3

33.5 ± 30.6

127.4±36.3^a

166.2 ± 23.0

38.8 ± 28.8

134.6 ± 30.7

118.4 ± 35.8^b,c

−16.2 ± 26.2^b†,c†

SSSI (μU/mL)

50.4 ± 15.8

46.4 ± 14.7

−4.0 ± 22.3

48.7±16.9

52.0 ± 16.7

3.3 ± 11.0

49.4 ± 14.3

54.8 ± 13.6

5.4 ± 9.2

BFI (μU/mL)

<2.5

<2.5

<2.5

<2.5

<2.5

<2.5