Type of defect | Lipoprotein increased | Pathological effects |
Familial hypercholestemia | LDL | Defective or lack of LDL receptors |
Familial defective apoB | LDL | apoB with LDL receptor binding |
Familial combined hyperlipoproteinemia | VLDL and LDL | Overproduction of apoB containing lipoproteins |
Dysbetalipoproteinemia | Remnants | Abnormal apoE |
Hypertriglyceridemia | Moderate-VLDL, Severe VLDL and Chylomicrons | Over production of triglyceride; defective catabolism |
Genetic lipoprotein lipase or apo CII deficiency | Chylomicrons | Defective catabolism |