|
| G1 N = 64 | G2 N = 136 | G3 N = 201 | P value |
| Mean age (years ± SD) | 46.7 ± 12.65 | 51.6 ± 13.03 | 56.3 ± 13.58 | <0.001 |
| General condition (WHO), n (%) |
|
|
|
|
| 0 | 43 (67) | 71 (52) | 58 (28.9) |
|
| 1 | 20 (31) | 53 (39) | 107 (53.2) | <0.001 |
| 2 | 1 (2) | 5 (4) | 24 (11.9) |
|
| ≥3 | 0 | 7 (5) | 12 (6) |
|
| Metastases, n (%) |
|
|
|
|
| Metachronous | 28 (44.3) | 82 (60.3) | 62 (30.8) | <0.001 |
| Synchronous | 36 (55.7) | 54 (39.7) | 139 (69.2) |
|
| Mean time of occurrence of metastases (months ± SD) | 14.1 ± 12.25 | 12.5 ± 12.04 | 18.9 ± 13 | <0.001 |
| Localizations of metastases, n (%) |
|
|
|
|
| Liver | 28 (44.1) | 71 (52) | 144 (71.6) |
|
| Lung | 2 (3.4) | 6 (4.6) | 45 (22.4) | <0.001 |
| Peritoneum | 15 (23.7) | 21 (15.3) | 42 (20.9) |
|
| Ovary | 1 (1.7) | 2 (1.5) | 25 (12.4) |
|
| Others | 18 (27.1) | 36 (26.6) |
|
|
| Normal liver function tests, n (%) |
|
|
|
|
| Yes | 45 (70.2) | 110 (81.3) | 136 (67.6) | 0.1 |
| No | 16 (25.5) | 23 (16.4) | 22 (10.9) |
|
| Not specified | 3 (4.3) | 3 (2.3) | 43 (21.5) |
|
| Normal initial level of CEA n (%) |
|
|
|
|
| Yes | 38 (60) | 80 (59.1) | 64 (31.8) | 0.01 |
| No | 26 (40) | 54 (39.9) | 92 (45.8) |
|
| Not specified | 0 | 2 (1) | 45 (22.4) |
|