Case | Dose of SBI (g/d) | Initial Response and Total Time on Therapy (wks) | Symptom Response | Overall Symptom Improvement |
1 | 5 | nd, 10 | Significantly decreased symptoms including bloating/distention, and diarrhea | 75% - 100 % |
2 | 5 | nd, 24 | Decreased bloating/distention and abdominal pain | 50% - 75% |
3 | 5 | nd, 8 | Improved abdominal pain, bloating/distention, and diarrhea | 50% - 75% |
4 | 5 | nd, 4 | Significant improvement in bloating and distention | 75% - 100% |
5 | 5 | nd, 6 | Decreased bloating, frequency, and urgency sensation in less than one month on therapy. One watery stool first followed by 2 soft stools per day. Metronidazole 10-day course and dicyclomine as needed were prescribed along with SBI. Now the patient is managed continuously on SBI with loperamide as needed. | 75% - 100% |
6 | 5 | 2, 10 | In one week, bloating and diarrhea improved. Continued improvement of bloating, diarrhea, and symptoms of GERD over a 9 week period. When patient stopped SBI for Nissen Fundoplication, symptoms of bloating and diarrhea returned. Re-initiation of SBI therapy resolved symptoms once again after 2-weeks. | 75% - 100% |
7 | 5 | nd, 12 | Significant decrease in bloating and distention | 50% - 75% |
8 | 5 | nd, 24 | Significant decrease in bloating in 8 wks with continued improvement in abdominal pain, bloating/distention and diarrhea thereafter. Patient still has recurrent nausea with vomiting and could not tolerate PPI therapy. Patient was also placed on dicyclomine to manage condition. | 50% - 75% |
9 | 5 | 2, 10 | Bowel movements were formed after morning meal with no urgency. Bismuth subsalicylate was discontinued. No abdominal cramping was reported after SBI administration. | 75% - 100% |
10 | 5 | 2, 28 | Normally formed bowel movements with notably reduced urgency. Patient self trial off SBI resulted in watery loose stool several times a day. This was resolved with re-initiation of SBI therapy within 2-weeks. | 50% - 75% |