Drug

Vaughan Williams

Indication

Onset of action

Half life

Protein binding

and metabolism

Route of

elimination

Dronedarone

All four classes of Vaughan Williams

To decrease the chances of hospitalization in case of sudden/continual AF/AFL with current episode of AF/AFL & related CV risk factors [17]

4 - 8 h

13 - 19 h

>98% by CYP3A and CYP2D6 [23]

~renal (6%) and

feces (84%) [24]

Amiodarone

All I - IV classes, but predominantly

Class III

Paroxysmal supra-ventricular tachycardia (paroxysmal SVT); Recurrent ventricular fibrillation; Supra-ventricular arrhythmias; Unstable ventricular tachycardia; Recurrent supra-ventricular tachycardia; Management of acute AF and long term treatment to prevent recurrence of AF [22]

Few days to weeks (1 - 3)

40 - 55 days

>96%, by CYP3A4 and CYP2C8 [25]

Metabolized by liver & biliary excretion [26]