Compd | IC50 (µmol/L) | ||
SK-N-SH | MGC-803 | HepG-2 | |
1a | 12.01 ± 1.27 | >100 | 38.02 ± 1.87 |
1b | 5.98 ± 1.06 | 12.99 ±2.62 | 64.17 ± 2.06 |
1c | 14.91 ± 1.85 | 12.84 ± 1.87 | 34.55 ± 3.51 |
1d | >100 | 13.73 ± 2.46 | 30.30 ± 2.43 |
1e 1f 1g 1h | 31.36 ± 2.01 2.63 ± 0.76 61.25 ± 3.21 0.87 ± 0.28 | 33.84 ± 2.85 24.83 ± 1.97 40.40 ± 3.41 >100 | 33.82 ± 2.01 57.33 ± 2,53 32.02 ± 1.98 27.46 ± 1.63 |
2a | 34.78 ± 3.56 | 43.75 ± 3.78 | >100 |
2b 2c | 76.23 ± 2.18 26.87 ± 1.87 | >100 >100 | >100 49.34 ± 1.76 |
2d | 48.95 ± 2.14 | >100 | >100 |
2e | >100 | >100 | >100 |
4a | 14.54 ± 1.43 | 43.19 ± 2.86 | 58.17 ± 3.01 |
4b | 12.76 ± 1.52 | >100 | >100 |
8a | >100 | >100 | >100 |
8b | 31.80 ± 2.07 | 36.86 ± 3.41 | 27.63 ± 2.43 |
8c | 64.31 ± 2.65 | 78.37 ± 4.01 | 43.98 ± 3.01 |
Isopetasinol | >100 | >100 | >100 |
Petasin Cisplatin | 5.76 ± 0.98 12.32 ± 1.06 | 34.41 ± 2.75 10.88 ± 1.86 | 26.84 ± 1.65 8.14 ± 0.89 |