Univariate

Multivariate

Stage 1 + 2:^a

HR

95% CI

P

HR

95% CI

P

Gender

Female (n = 124)

1.00

ref

1.00

ref

Male (n = 165)

1.88

1.35 - 2.60

0.0002

1.71

1.21 - 2.43

0.002

Age

<70 (n = 135)

1.00

ref

1.00

ref

≥70 (n = 154)

2.75

1.98 - 3.82

<0.001

1.69

1.14 - 2.49

0.009

Performance status

0-1 (n = 233)

1.00

ref

1.00

ref

2-4 (n = 56)

6.06

4.17 - 8.81

<0.001

2.29

1.40 - 3.74

0.0009

Stage 3:^b

Gender

Female (n = 141)

1.00

ref

1.00

ref

Male (n = 281)

1.42

1.14 - 1.77

0.002

1.33

1.05 - 1.69

0.017

Age

<70 (n = 177)

1.00

ref

1.00

ref

≥70 (n = 245)

1.53

1.24 - 1.89

<0.001

0.85

0.67 - 1.08

0.188

Performance status

0-1 (n = 239)

1.00

ref

1.00

ref

2-4 (n = 183)

3.52

2.83 - 4.39

<0.001

2.06

1.60 - 2.65

<0.001

Stage 4:^c

Gender

Female (n = 222)

1.00

ref

1.00

ref

Male (n = 298)

1.09

0.91 - 1.30

0.350

1.00

0.83 - 1.20

0.968

Age

<70 (n = 279)

1.00

ref

1.00

ref

≥70 (n = 241)

1.20

1.01 - 1.43

0.042

0.68

0.56 - 0.83

0.0002

Performance status

0-1 (n = 167)

1.00

ref

1.00

ref

2-4 (n = 353)

3.19

2.61 - 3.88

<0.001

2.80

2.25 - 3.47

<0.001