Decosterd & Woolf 2000

Shields et al. 2003

Bourquin et al. 2006

Species/Strain

Sprague Dawley Rats

C57BL/6 mice

C57BL/6 mice

Gender

Male

Male & Female

Male

Weight/Age

200 - 250 g (age not specified)

20 - 25 g (age not specified)

25 - 30 g/2months old

Anesthesia

Halothane (2%)

Ketamine & Xylazine (60 and 8 mg/kg) OR Halothane (1.75% - 2.5%)

Isoflurane (1.5% - 2.5%)

Side of Injury

Not specified

Not specified

Left hindlimb

Injury

Tibial ligated/peroneal ligated; both severed, 2-4mm stumps removed distal to ligations

Tibial ligated/peroneal ligated; both severed

Tibial + peroneal ligated together; 1 - 2 mm stumps removed distal to ligation

Nerve Ligation

5-0 silk

9-0 silk

6-0 silk

Muscle Suture

Not specified

6-0 silk

6-0 silk

Skin Suture

Not specified

6-0 silk

6-0 silk & surgical micro clips

Mechanical Allodynia

Yes

Not with Ketamine/Xylazine;

Not with Halothane

Yes

Cold Allodynia

Yes

Not determined

Not determined