Tomsk, Russia [5] | DOTS Plus pilot projects [7] | Lima, Peru [6] | Present Study | |
Study type | Retrospective | Retrospective | Retrospective | Retrospective |
No of cohort | 244 | 818 | 60 | 607 |
Adverse reactions | ||||
% | % | % | % | |
Gastrointestinal (nausea, vomiting, pain abdomen) | 75.4 | 61.2 | 100 | 71.1 |
Nephrotoxicity | 9.8 | 1.2 | 3.3 | 0.5 |
Hepatotoxicity | 16.8 | 2.2 | 1.7 | 1.2 |
Hypothyroidism | 17.2 | 3.5 | 10 | 3.1 |
Depression | 8.6 | 6.2 | 18.3 | 13 |
Psychosis | 11.9 | 3.4 | 10 | 1.6 |
Seizures | 11.5 | 4 | 8.3 | 2.5 |
Oto-vestibular toxicity | 15.6 | 12 | 6.7 | 3 |
Arthralgia | 47.1 | 16.4 | 6.7 | 14 |
Dermatologic | 16 | 4.6 | 43.3 | 4.3 |
Neuropathy | 4.1 | 7.9 | 20 | 5.8 |
Opthalmic | _ | 4.4 | _ | 0.2 |
Diarrhoea | 46.3 | 21.1 | _ | 8.6 |