Tomsk, Russia [5]

DOTS Plus pilot projects [7]

Lima, Peru [6]

Present Study

Study type

Retrospective

Retrospective

Retrospective

Retrospective

No of cohort

244

818

60

607

Adverse reactions

%

%

%

%

Gastrointestinal (nausea, vomiting, pain abdomen)

75.4

61.2

100

71.1

Nephrotoxicity

9.8

1.2

3.3

0.5

Hepatotoxicity

16.8

2.2

1.7

1.2

Hypothyroidism

17.2

3.5

10

3.1

Depression

8.6

6.2

18.3

13

Psychosis

11.9

3.4

10

1.6

Seizures

11.5

4

8.3

2.5

Oto-vestibular toxicity

15.6

12

6.7

3

Arthralgia

47.1

16.4

6.7

14

Dermatologic

16

4.6

43.3

4.3

Neuropathy

4.1

7.9

20

5.8

Opthalmic

_

4.4

_

0.2

Diarrhoea

46.3

21.1

_

8.6