Types

Description

ATP competitive inhibitors

· Binds to the ATP binding site of the kinase in its active conformation

Inhibitors

· Binds to non-active conformation of ATP bindingsite

Allosteric inhibitors

· Binds to the outside of ATP binding site

· Modifies tridimensional structure of the receptor

· Disrupt interaction between ATP and its kinase bindingsite

Covalent inhibitors

· Irreversible binding of ATP binding site of kinase