Organism

Gene(s)

Editing

Reference

Mouse

ASXL1

Non sense point mutation

[87]

Mice

Human ICC/HCC

Multiplex mutagenesis

[88]

Human

CFTR

Homozygous deletion of F508

[89]

Mouse

Crygc

Correction of genetic disease

[90]

Mice

Dystrophin gene (Dmd)

Destrophin related duchenne muscular dystrohy

[91]

Human

Cas9 nuclease and nickase

Fanconi anemia gene correction

[92]

Mouse

AAV9

Postnatal genome editing

[93]

Mouse

Fah

In vivo therapies

[94]

Mouse

PCSK9

Mouse hepatocyte editing

[95]

Mammalian brain

CHD8

Autism spectrum disorder

[96] [97]

Wild mice

PTEN & TP53

Tumor suppressor genes

[98] [99] [100]

Human

HIV-I

virus

[101] - [107]

Human

Burkitt’s Lymphoma cells

Latent Herpesviridae

[108]

Human

HPV16-E7

Papillomavirus

[109]

Humans

HBV cccDNA

Hepatitis-B

[110]

Human

CXCR4 & CCR5

AIDS

[107] [108] [111]

Pig

PERVs

Viral disruption

[112]

Human

Pig Alb locus

Human Albumin production

[112]

Corn

LIG1, Ms26 and Ms45, ALS1 and 2

Targeted mutagenesis, Precise gene editing, Site specific gene insertion

[113]

Soybean

DD20 and DD43

Genome editing

[111]

Nicotiana benthamiana

----------

Tomato Yellow Leaf Curl Virus

[114]

Mushrooms

----------

CRISPR Edited Mushrooms

[115]