Shc Construct	Ligand	K_d (µM)	ΔH (kJ/mol)	−TΔS (kJ/mol)	ΔG (kJ/mol)
PTB Domain	bi-β₃ bi-β₃ + Ins_(1,4,5)P₃	4.32	−11.52	−17.75	−29.27
	bi-β₃ bi-β₃ + Ins_(1,4,5)P₃	3.65	−12.37	−17.30	−29.66
	c-β₃ c-β₃ + Ins_(1,4,5)P₃	1.05	−24.18	−8.45	−32.63
	c-β₃ c-β₃ + Ins_(1,4,5)P₃	1.12	−23.62	−8.84	−32.46
Full Length	bi-β₃ bi-β₃ + Ins_(1,4,5)P₃	5.21	−16.27	−12.55	−28.82
	bi-β₃ bi-β₃ + Ins_(1,4,5)P₃	4.38	−13.87	−15.37	−29.23
	c-β₃ c-β₃ + Ins_(1,4,5)P₃	0.82	−21.03	−12.17	−33.20
	c-β₃ c-β₃ + Ins_(1,4,5)P₃	0.87	−21.11	−11.96	−33.07